Pharm Ingredients
Betulinic Acid Powder
What is Betulinic Acid Powder?
Looking for high-quality 98% betulinic acid powder from white birch? Kintainutri®, a Chinese manufacturer with ISO, cGMP, and HACCP certifications, offers bulk betulinic acid. As a professional herbal extract manufacturer, we strictly adhere to GMP standards to ensure top-notch quality. If want to buy bulk and pure 98% betulinic acid powder, feel free to contact us directly!
Betulinic acid powder is mainly compounds extracted from the bark of birch trees. It is a naturally occurring pentacyclic triterpeniod compound. It has a series of effects such as anti-tumor, anti-inflammatory, and antiviral, and has played a significant role in the field of pharmacy.
Betulinic Acid Powder Chemical & Physical Properties
Chemical Name |
3β-hydroxy-lup-20(29)-ene-28-oic acid |
Appearance |
White Crystalline Powder |
Specification |
98% |
CAS No. |
472-15-1 |
Molecular Formula |
C30H48O3 |
Solubility |
Insoluble in water, slightly soluble in methanol, ethanol, acetone, |
Molecular Structure |
 |
Betulinic Acid Powder Specification
| ITEM | STANDARD | TEST METHOD | |
|---|---|---|---|
| Betulinic Acid | 98% | HPLC | |
| Physical & Chemical | |||
| Appearance | White Fine Powder | Visual | |
| Odor & Taste | Characteristic | Organoleptic | |
| Particle Size | 98% pass 80 mesh | USP<786> | |
| Loss on drying | ≤5.0% | USP<731> | |
| Ash | ≤5.0% | USP<281> | |
| Heavy Metal | |||
| Pb | ≤2.0ppm | ICP-MS | |
| As | ≤1.0ppm | ICP-MS | |
| Cd | ≤1.0ppm | ICP-MS | |
| Hg | ≤0.5ppm | ICP-MS | |
| Microbiological Test | |||
| Total Plate Count | ≤1,000cfu/g | AOAC | |
| Mold and Yeast | ≤100cfu/g | AOAC | |
| E.Coli | Negative | AOAC | |
| Salmonella | Negative | AOAC | |
Betulinic Acid Powder Benefits
Betulinic acid anticancer activity
As a high-purity, natural pentacyclic triterpene active ingredient, betulinic acid holds the potential to become a sought-after product in the field of anticancer active pharmaceutical ingredients (APIs), owing to its unique mitochondria-targeting mechanism. It precisely induces permeabilization of the mitochondrial outer membrane in tumor cells, triggering the release of cytochrome c and the subsequent caspase cascade to efficiently initiate cancer-cell-specific apoptosis.
Furthermore, it exhibits an excellent safety profile regarding normal cells and a clear therapeutic window. Betulinic acid powder has demonstrated unique properties in mechanistically modulating oncogenic transduction cascades, underscoring its significant anticancer potential.
Betulinic acid antiviral
Betulic acid exhibits broad-spectrum antiviral activity by interfering with viral RNA replication and protein synthesis. It has demonstrated significant in vitro inhibitory effects against dengue virus (DENV), Zika virus, and chikungunya virus, making it a promising candidate for the development of therapeutics targeting mosquito-borne RNA viruses.
Beyond mosquito-borne viruses, betulinic acid has also shown antiviral potential against HIV, hepatitis C virus (HCV), herpes simplex virus (HSV), coxsackievirus, influenza virus, and other viral pathogens. These findings highlight its value as a promising lead compound for the development of novel broad-spectrum antiviral agents.
Betulinic acid for horses
As an innovative raw material that has attracted much attention from the equine veterinary medicine and high-end pet health care product industries, betulinic acid has excellent transdermal absorption and targeted anti-tumor mechanisms. After topical administration, lupatic acid powder cream with a concentration of 1% can efficiently penetrate and target equine melanoma and sarcoma cells. By inducing specific apoptosis of tumor cells, the tumor volume can be significantly reduced within 90 days. It has shown great commercial and application value in the clinical treatment of equine skin malignant tumors.
Betulinic acid skin
Betulinic acid (BA) exhibits multiple bioactivities in skin health applications. It exerts potent anti-inflammatory effects by inhibiting NF-κB signaling and reducing the expression of pro-inflammatory cytokines such as IL-17A and IL-6, thereby alleviating psoriasis-like skin inflammation. In addition, BA promotes collagen synthesis and regulates the SIRT1–p53 pathway, contributing to skin repair and anti-aging benefits. It also demonstrates selective pro-apoptotic activity against melanoma cells, highlighting its potential in dermato-oncology applications.
Betulinic Acid Powder Uses
Betulinic acid supplement
As a functional ingredient of natural plant origin, betulinic acid offers significant commercial value in the oral dietary supplement sector. It is suitable for developing products targeting weight management, liver health, and blood lipid regulation, thereby addressing the specific needs of individuals in a sub-health state.
Its natural origin aligns with the "clean label" trend, and it demonstrates excellent compatibility with mainstream functional ingredients such as berberine and silymarin. Furthermore, formulation technologies such as liposomal delivery and microencapsulation enable its incorporation into a variety of dosage forms, including softgels, solid beverages, and functional gummies.
Betulinic acid cream
Betulinic acid is garnering widespread attention as a natural antioxidant additive. Betulinic acid creams effectively scavenge highly reactive free radicals, thereby reducing oxidative damage to skin cell DNA. Furthermore, betulinic acid significantly counteracts cellular stress and photodamage induced by ionizing radiation, such as ultraviolet rays, effectively delaying photoaging at its source. These multifaceted protective properties make it an ideal active ingredient for sunscreens and anti-aging repair creams, offering both protection and repair capabilities to meet the growing market demand for precision skincare and photoprotection.
Why Choose Betulinic Acid Powder by Kintainutri®?
In vivo studies indicate that betulinic acid powder may present certain toxicity risks. One study reported that administration at a dose of 30 mg/kg resulted in elevated alanine aminotransferase (ALT) levels, suggesting potential hepatotoxicity. Therefore, lower doses are recommended for in vivo studies to ensure safety.
Aside from this finding, betulinic acid has not been associated with other significant systemic toxicity or with mutagenic, tumorigenic, or teratogenic effects. Overall, the primary safety concern of BA appears to be dose-dependent liver toxicity at relatively high doses, and its therapeutic safety window requires further toxicological and clinical investigation.
Why Choose Betulinic Acid Powder by Kintainutri®?
1. We promise that our raw materials are naturally grown without any additives.
2. We provide customized extraction solutions to produce betulinic acid powder in various specifications tailored to your requirements.
3. Our production facilities hold internationally recognized certifications including GMP, ISO 9001, ISO 22000, HACCP, KOSHER, and HALAL, guaranteeing the highest standards for your peace of mind.
Reference:
[1]: https://pmc.ncbi.nlm.nih.gov/articles/PMC2658785/
[2]: https://pubmed.ncbi.nlm.nih.gov/33080251/
[3]: https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1821503/full
[4]: https://www.mdpi.com/2075-1729/15/6/954
[5]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9168372/
[1]: https://pmc.ncbi.nlm.nih.gov/articles/PMC2658785/
[2]: https://pubmed.ncbi.nlm.nih.gov/33080251/
[3]: https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1821503/full
[4]: https://www.mdpi.com/2075-1729/15/6/954
[5]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9168372/
